A case report recently published in Pain Medicine Case Reports (Vol. 10, No. 3, 2026) describes for the first time the use of autologous microfragmented adipose tissue (MFAT) for the treatment of refractory generator pocket pain (GPP) in a spinal cord stimulation (SCS) patient.
GPP is a complication affecting up to 64% of SCS patients and, in severe cases, leads to device relocation or removal. In this case, the clinical team at Verona University Hospital processed abdominal fat using the LIPO-STEM DUO™ system and injected 30 mL of MFAT directly into the generator pocket. The result was an immediate reduction in pain intensity, VAS score dropping from 80 to 20/100, sustained at three-month follow-up, with no adverse events.
The authors identify three mechanisms of action: mechanical cushioning, soft tissue regeneration, and the immunomodulatory properties of MFAT. This represents the first documented experience in the literature for this indication.
We are proud that LIPO-STEM DUO™ contributed to this pioneering procedure, further confirming the role of regenerative medicine as an ever-expanding therapeutic frontier.
Read the full article: https://pubmed.ncbi.nlm.nih.gov/42263293/
